Intermediate Levels Of Activity Research Articles

Characterisation of the stellar activity of M dwarfs

Context. The chromospheric emission estimated in the core of different lines, such as Ca II H & K, Na D1 and D2, and Ha, is not always correlated between lines. In particular, the Ca II H & K and Ha emission time series are anti-correlated for a few percent of the stars, contrary to what is observed on the Sun. This puzzling result has been observed for both solar-type stars and M stars. Aims. Our objective is to characterise these relationships in more detail using complementary criteria, and based on a large set of spectra obtained with HARPS for a large sample of M dwarfs. This should allow to evaluate whether or not additional processes are required to explain the observations. Methods. We analysed the time average and variability of the Ca, Na, and Hα emissions for 177 M stars ranging from subspectral types M0 to M8, paying particular attention to their (anti-)correlations on both short and long timescales as well as slopes between indices. We also computed synthetic Hα time series based on different assumptions of plage properties. We compared our findings with observations in order to evaluate whether or not the main observed properties could be reproduced. Results. The statistical properties of our sample, in terms of correlations and slopes between indices at different timescales, differ from what we previously obtained for FGK stars: there are fewer stars with a null correlation, and the correlations we find show a weaker dependence on timescale. However, there can be a large dispersion from one season to another for stars with a well identified low or negative correlation. We also specify the complex relationship between the average activity levels, with a clear indication of a change in the sign of the slope from the relation between Ca and Hα (and between Na and Ha) for the most massive M dwarfs. In addition, we observe a change in slope in the Na–Ca relation at an intermediate activity level. At this stage, we are not able to find simple plage properties that, alone, are sufficient to reproduce the observations. However, the simulations already allow us to point out that it is not straightforward to compare the temporal variability correlation and the integrated indices. Our findings also demonstrate the need for complex activity patterns to explain some of the observations. Conclusions. We conclude that the relation between the three indices examined here exhibits a large diversity in behaviour over the sample studied. More detailed simulations with complex activity patterns are necessary to understand these observations. This will teach us about plage properties for this type of star.

Modelling operator control work across traffic management domains: implications for interaction design

AbstractTraffic management in aviation, shipping, and rail transport shows similarities and dissimilarities in the work process. For example, they share the temporal aspect, but different levels of urgency in the control work set different requirements on monitoring, decisions, and actions. However, few studies have been presented that model and compare the different domains in terms of temporal decision-making. The Joint Control Framework (JCF) is an approach to analyse and temporally model operators’ control processes from a cognitive systems engineering perspective. In this study, we have used JCF to map, and compare, cognitive joints, such as perceptions, decisions, and actions, in temporally challenging control situations in air traffic control, maritime vessel traffic service, and train traffic management. Data was collected collaboratively with traffic operators, focusing on (1) identifying challenging traffic situations and (2) jointly modelling the temporal decision-making patterns of these situations using simplified JCF. Post-analysis was done by breaking down the results into different processes and comparing domains to ascertain how operators maintain control. An intermediate level of activity—between general monitoring and work with specific vehicles—was identified: processes-in-focus. A shared problem arises in the shift between general monitoring and the processes-in-focus. All processes-in-focus comprise cognitive joint cycles of perceptions, decisions, and actions. However, depending on the framing of processes-in-focus, the patterns of joints, such as temporal extension and complexity, differ. In the remainder of the article, implications for the interaction design, in particular the potential for human–AI/automation teaming with higher levels of automation and cognitive autonomy, are discussed.

Stochastic resonance in sparse neuronal network: functional role of ongoing activity to detect weak sensory input in awake auditory cortex of rat.

The awake cortex is characterized by a higher level of ongoing spontaneous activity, but it has a better detectability of weak sensory inputs than the anesthetized cortex. However, the computational mechanism underlying this paradoxical nature of awake neuronal activity remains to be elucidated. Here, we propose a hypothetical stochastic resonance, which improves the signal-to-noise ratio (SNR) of weak sensory inputs through nonlinear relations between ongoing spontaneous activities and sensory-evoked activities. Prestimulus and tone-evoked activities were investigated via in vivo extracellular recording with a dense microelectrode array covering the entire auditory cortex in rats in both awake and anesthetized states. We found that tone-evoked activities increased supralinearly with the prestimulus activity level in the awake state and that the SNR of weak stimulus representation was optimized at an intermediate level of prestimulus ongoing activity. Furthermore, the temporally intermittent firing pattern, but not the trial-by-trial reliability or the fluctuation of local field potential, was identified as a relevant factor for SNR improvement. Since ongoing activity differs among neurons, hypothetical stochastic resonance or "sparse network stochastic resonance" might offer beneficial SNR improvement at the single-neuron level, which is compatible with the sparse representation in the sensory cortex.

Cost-utility analysis of endoscopic lumbar discectomy following a uniform clinical pathway in the Korean national health insurance system.

Full-endoscopic lumbar discectomy (FELD) is a type of minimally invasive spinal surgery for lumbar disc herniation (LDH). Sufficient evidence exists to recommend FELD as an alternative to standard open microdiscectomy, and some patients prefer FELD due to its minimally invasive nature. However, in the Republic of Korea, the National Health Insurance System (NHIS) controls the reimbursement and use of supplies for FELD, but FELD is not currently reimbursed by the NHIS. Nonetheless, FELD has been performed upon patients' request, but providing FELD for patients' sake is inherently an unstable arrangement in the absence of a practical reimbursement system. The purpose of this study was to conduct a cost-utility analysis of FELD to suggest appropriate reimbursements. This study was a subgroup analysis of prospectively collected data including 28 patients who underwent FELD. All patients were NHIS beneficiaries and followed a uniform clinical pathway. Quality-adjusted life years (QALYs) were assessed with a utility score using the EuroQol 5-Dimension (EQ-5D) instrument. The costs included direct medical costs incurred at the hospital for 2 years and the price of the electrode ($700), although it was not reimbursed. The costs and QALYs gained were used to calculate the cost per QALY gained. Patients' mean age was 43 years and one-third (32%) were women. L4-5 was the most common surgical level (20/28, 71%) and extrusion was the most common type of LDH (14, 50%). Half of the patients (15, 54%) had jobs with an intermediate level of activity. The preoperative EQ-5D utility score was 0.48±0.19. Pain, disability, and the utility score significantly improved starting 1 month postoperatively. The average EQ-5D utility score during 2 years after FELD was estimated as 0.81 (95% CI: 0.78-0.85). For 2 years, the mean direct costs were $3,459 and the cost per QALY gained was $5,241. The cost-utility analysis showed a quite reasonable cost per QALY gained for FELD. A comprehensive range of surgical options should be provided to patients, for which a practical reimbursement system is a prerequisite.

Modulation of the canonical Wnt activity by androgen signaling in prostate epithelial basal stem cells.

Both the canonical Wnt and androgen receptor (AR) signaling pathways are important for prostate organogenesis and homeostasis. How they crosstalk to regulate prostate stem cell behaviors remains unclear. Here, we show in lineage-tracing mouse models that although Wnt is essential for basal stem cell multipotency, ectopic Wnt activity promotes basal cell over-proliferation and squamous phenotypes, which are counteracted by elevated levels of androgen. In prostate basal cell organoids, dihydrotestosterone (DHT) antagonizes R-spondin-stimulated growth in a concentration-dependent manner. DHT down-regulates the expressions of a Wnt reporter and target genes, and RNA sequencing (RNA-seq) analyses identify Wnt signaling as a key altered pathway. Mechanistically, DHT enhances AR and β-catenin protein binding, and CUT&RUN analyses reveal that ectopic AR sequesters β-catenin away from its Wnt-related cistrome. Our results suggest that an intermediate level of Wnt activity in prostate basal stem cells, achieved via AR-β-catenin interaction, is essential for normal prostate homeostasis.

A prospective 18 F-fluorodeoxyglucose positron emission tomography/computed tomography study of the neurometabolic effects in cocaine use and HIV infection.

HIV affects 36 million people globally with prevalence decreasing due to antiretroviral therapy (ART) and social awareness; transmission occurs during substance use. Cocaine usage independently affects brain activity and may result in reduced ART adherence. This study evaluates brain glucose metabolism measured by 18 F-fluorodeoxyglucose positron emission tomography/computed tomography ( 18 F-FDG PET/CT) in cocaine users with HIV infection. Sixty-three participants were categorized into groups: 36 HIV infected (HIV+) and 27 non-HIV infected (HIV-) individuals. Each group was further split into cocaine users (CO+) and non-cocaine users (CO-). Of the HIV+, half were cocaine users and half were not. Of the HIV-, 14 were cocaine users and 13 were not. 18 F-FDG-PET and low dose CT scans were performed on all participants. Brain glucose metabolism was evaluated by 18 F-FDG uptake in the whole brain, cortex, basal ganglia, and cerebellum 120 min after injection. ROVER software was used for image analysis and regions of interest masks were applied via an adaptive threshold system. ANOVA tests and t -tests were performed to assess the respective differences between the four groups. Generally, the HIV+/CO+ group (group A) displayed the lowest levels of uptake whereas the HIV-/CO- group (group D) showed the highest; the HIV+/CO- and HIV-/CO+ groups (groups B and C) showed intermediate levels of activity across the whole brain, cortex, basal ganglia, and cerebellum. HIV infection and cocaine usage were independently associated with a decrease in brain glucose uptake as measured by 18 F-FDG PET/CT. When combined, positive HIV status and cocaine patients showed the most decreased 18 F-FDG uptake.

Data Mining for Estimating the Impact of Physical Activity Levels on the Health-Related Well-Being

The main objective of this paper is to employ some multifactorial data mining techniques for studying the direct and indirect effects of the physical activity intensity on persons’ health-related well-being. The availability of such a data-driven modeling and simulation interface enables analysts and decision makers to boost their decision by better understanding the types and levels of relationships between the main factors promoting the well-being of individuals. The data mining investigation is conducted at the CHU Gabriel Montpied (Clermont-Ferrand, France) on a population of employees, composed of medical and nonmedical staff. An observation-like study is conducted with the main aim of assessing direct and indirect effects of the physical activity intensity on the population’s health. This is especially performed by examining the significance of associations between physical activity indices and a set of their medical records. One of the main models resulting from data mining in this paper links cardiovascular risks to a set of exogenous variables including work and sport activity indices. The empirical results are consistent with many recent findings emphasizing the role of increasing high and intermediate levels of physical activity among health public-sector employees to effectively fight some diabetic and cardiovascular diseases.

Encapsulation of β-carotene into food-grade nanofibers via coaxial electrospinning of hydrocolloids: Enhancement of oxidative stability and photoprotection

Εncapsulation of β-carotene in two different food hydrocolloid matrices, pure pullulan (PUL) and its blend with whey protein isolate (WPI) at a weight ratio of WPI:PUL 30:70, via coaxial electrospinning, was investigated. Τhe encapsulation efficiency of β-carotene in the generated WPI:PUL (30:70 w/w) and PUL nanofibers has reached up to ∼90% and ∼95%, respectively. Among the various operating parameters examined, the factor which had the greatest impact on encapsulation efficiency was the oil-β-carotene solution (core material) flow rate. More uniform thread-like nanofibers were obtained using pure pullulan as wall material, while the WPI:PUL (30:70 w/w) blend resulted in formation of nanostructures with bead-shaped morphologies periodically along the fiber axis. The β-carotene degradation kinetics followed an apparent first-order reaction model, showing highest values of the rate constants at an intermediate water activity level (aw = 0.53) for all matrices and storage temperatures (25 °C, 35 °C, 45 °C) examined. The degradation kinetics did not seem to be directly related with the molecular mobility of the fiber polymeric components (i.e., physical state of the amorphous wall material), as β-carotene losses were evident even at temperatures below their glass transition temperatures ( T g ). The electrospun WPI:PUL nanofibers were more suitable as carriers in delaying oxidation of β-carotene under different storage temperatures, a w levels and exposure to UV–Vis irradiation, compared to pure PUL. Overall, the coaxial electrospinning process using the mixture of WPI:PUL (30:70 w/w) as an encapsulation vehicle appears to be an effective technique to fabricate functional foods or dietary supplements enriched with β-carotene. • β-carotene was encapsulated through coaxial electrospinning for food applications. • β-carotene can be effectively encapsulated in WPI:PUL (30:70) and PUL nanofibers. • β-carotene solution flow rate had the greatest impact on encapsulation efficiency. • Both encapsulation structures showed improved stability at low humidity environments. • Electrospun WPI:PUL (30:70) nanofibers were more effective than PUL ones.

Investigation of the Thermal Stability of Proteinase K for the Melt Processing of Poly(l-lactide).

The enzymatic degradation of aliphatic polyesters offers unique opportunities for various use cases in materials science. Although evidently desirable, the implementation of enzymes in technical applications of polyesters is generally challenging due to the thermal lability of enzymes. To prospectively overcome this intrinsic limitation, we here explored the thermal stability of proteinase K at conditions applicable for polymer melt processing, given that this hydrolytic enzyme is well established for its ability to degrade poly(l-lactide) (PLLA). Using assorted spectroscopic methods and enzymatic assays, we investigated the effects of high temperatures on the structure and specific activity of proteinase K. Whereas in solution, irreversible unfolding occurred at temperatures above 75-80 °C, in the dry, bulk state, proteinase K withstood prolonged incubation at elevated temperatures. Unexpectedly little activity loss occurred during incubation at up to 130 °C, and intermediate levels of catalytic activity were preserved at up to 150 °C. The resistance of bulk proteinase K to thermal treatment was slightly enhanced by absorption into polyacrylamide (PAM) particles. Under these conditions, after 5 min at a temperature of 200 °C, which is required for the melt processing of PLLA, proteinase K was not completely denatured but retained around 2% enzymatic activity. Our findings reveal that the thermal processing of proteinase K in the dry state is principally feasible, but equally, they also identify needs and prospects for improvement. The experimental pipeline we establish for proteinase K analysis stands to benefit efforts directed to this end. More broadly, our work sheds light on enzymatically degradable polymers and the thermal processing of enzymes, which are of increasing economical and societal relevance.

Ideal cardiovascular health status and risk of cardiovascular disease and all-cause mortality: over a decade of follow-up in the Tehran lipid and glucose study

ObjectiveTo quantify the association between ideal cardiovascular health (CVH) metrics and incident cardiovascular disease (CVD) including different subtypes [coronary heart disease (CHD), stroke, and sudden death], and all-cause mortality in an Iranian population.MethodsThe study population included 6,388 participants (2,726 men) aged 48.0 ± 12.4 years free of CVD at baseline. We utilized the American Heart Association’s 2020 impact target criteria of ideal, intermediate, and poor CVH. The multivariate Cox proportional Hazard model, adjusted for age, sex, educational level, marital status, and family history of CVD, was applied to estimate the hazard ratio (HR) of outcomes per one additional metric of ideal CVH metrics. Furthermore, the risk was also calculated for ideal and intermediate categories considering poor category as a reference.ResultsDuring the median follow-up of 11.26 years, 692 CVD, 589 CHD, 130 stroke, 111 sudden death, and 519 all-cause mortality events were reported. All of the individual ideal CVH metrics were independent predictors except intermediate physical activity level for CVD, BMI < 25 kg/m2, and intermediate physical activity for all-cause mortality. Each additional metrics of ideal CVH decreased the risk by 31 (0.69, 0.65–0.73) for CVD, 32 (0.68, 0.64–0.73) for CHD, 31 (0.69, 0.60–0.80) for stroke, 25 (0.75, 0.64–0.88) for sudden death, and 13% (0.87, 0.81–0.93) for all-cause mortality events. Moreover, intermediate and ideal categories of CVH metrics were associated with lower risk for different CVD outcomes, i.e., 44 (0.56, 0.48–0.65) and 76% (0.24, 0.17–0.35) for CVD; 43 (0.57, 0.47–0.67) and 75% (0.25, 0.16–0.37) for CHD, 58 (0.42, 0.29–0.61) and 86% (0.14, 0.04–0.44) for stroke; 56 (0.44, 0.29–0.66) and 55% (0.45, 0.21–0.99) for sudden death; and 25 (0.75, 0.62–0.90) and 46% (0.54, 0.37–0.80) for all-cause mortality events, respectively. We also assessed the impact of changes in ideal CVH status from phase III to phase IV (2008–2011) on CVD events among 5,666 participants. Accordingly, compared to those remaining in the poor category, all of the changes in ideal CVH categories showed a lower risk for CVD events.ConclusionAmong the Iranian population, meeting higher ideal CVH metrics is associated with a lower risk of different CVD events and mortality outcomes.

Can Previous Levels of Physical Activity Affect Risk Factors for Cardiorespiratory Diseases and Functional Capacity after COVID-19 Hospitalization? A Prospective Cohort Study.

Purpose To evaluate the influence of previous levels of physical activity on hemodynamic, vascular, ventilatory, and functional outcomes after coronavirus disease 2019 (COVID-19) hospitalization. Methods Sixty-three individuals with COVID-19 had their clinical status and previous levels (12 month) of physical activity (Baecke Questionnaire of Habitual Physical Activity) assessed at hospital admission. Individuals were then allocated to lower levels of physical activity (ACTLOWER; N = 22), intermediate levels of physical activity (ACTINTERMEDIATE; N = 22), or higher levels of physical activity (ACTHIGHER; N = 19) groups, according to tertiles of physical activity. Resting hemodynamic (heart rate and brachial/central blood pressures) and vascular (carotid-femoral pulse wave velocity, augmentation index, and brachial artery flow-mediated dilation) variables, pulmonary function (spirometry), respiratory muscle strength (maximal respiratory pressures), and functional capacity (handgrip strength, five-time sit-to-stand, timed-up and go, and six-minute walking tests) were measured at 30 to 45 days after hospital discharge. Results ACTLOWER showed lower levels (P < 0.05) of forced vital capacity, forced expiratory volume in the first second, maximal voluntary ventilation, and maximal expiratory pressure than ACTHIGHER. ACTLOWER also had lower (P = 0.023) walking distance (~21%,) and lower percentage of predicted walking distance (~20%) at six-minute walking test during follow-up than ACTINTERMEDIATE. However, hemodynamic and vascular variables, handgrip strength, five-time sit-to-stand, and timed-up and go were not different among groups. Conclusion ACTLOWER showed impaired ventilatory parameters and walking performance when compared with ACTHIGHER and ACTINTERMEDIATE, respectively. These results suggest that previous levels of physical activity may impact ventilatory and exercise capacity outcomes 30 to 45 days after COVID-19 hospitalization discharge.

Human influence on burrow activity of the Chinese pangolin in Nepal

Context People and wildlife are coming into greater contact worldwide because of the increasing human footprint. Although some species tolerate certain levels of human activities, others are vulnerable to human disturbance, potentially altering their spatial or temporal patterns of activity in response to disturbance by humans. Aims We evaluated the influence of human activity on burrow activity of the Chinese pangolin, a Critically Endangered species that is heavily persecuted for subsistence and illegal trade. Methods We deployed remotely triggered camera traps at pangolin burrows located at four sites with contrasting levels of human density and infrastructure in Nepal, and estimated burrow-activity patterns of pangolins by using a kernel-density estimator based on the time stamp of camera trap observations. Key results Our findings did not suggest that anthropogenic disturbance affected pangolin burrow activity, but we acknowledge that these findings were based on a limited number of observations. Peak pangolin burrow activity was observed after midnight in three of the study sites, including those with highest and lowest levels of human activity. The fourth area, which had intermediate levels of human activity, had an earlier peak in burrow activity, possibly caused by prey deficiency owing to intense agriculture. Conclusions We suggest that pangolins may tolerate human activity because of their strictly nocturnal temporal niche, but that this tolerance has made them vulnerable to poaching because it allows them to co-exist spatially with humans. Implications Nocturnal species may be particularly prone to non-conflict-related persecution, because they may be easily accessible targets for illegal hunting activities.

Enriched Environment Modulates Sharp Wave-Ripple (SPW-R) Activity in Hippocampal Slices.

Behavioral flexibility depends on neuronal plasticity which forms and adapts the central nervous system in an experience-dependent manner. Thus, plasticity depends on interactions between the organism and its environment. A key experimental paradigm for studying this concept is the exposure of rodents to an enriched environment (EE), followed by studying differences to control animals kept under standard conditions (SC). While multiple changes induced by EE have been found at the cellular-molecular and cognitive-behavioral levels, little is known about EE-dependent alterations at the intermediate level of network activity. We, therefore, studied spontaneous network activity in hippocampal slices from mice which had previously experienced EE for 10–15 days. Compared to control animals from standard conditions (SC) and mice with enhanced motor activity (MC) we found several differences in sharp wave-ripple complexes (SPW-R), a memory-related activity pattern. Sharp wave amplitude, unit firing during sharp waves, and the number of superimposed ripple cycles were increased in tissue from the EE group. On the other hand, spiking precision with respect to the ripple oscillations was reduced. Recordings from single pyramidal cells revealed a reduction in synaptic inhibition during SPW-R together with a reduced inhibition-excitation ratio. The number of inhibitory neurons, including parvalbumin-positive interneurons, was unchanged. Altered activation or efficacy of synaptic inhibition may thus underlie changes in memory-related network activity patterns which, in turn, may be important for the cognitive-behavioral effects of EE exposure.

Moderately trained male football players, compared to sedentary male adults, exhibit anatomical but not functional cardiac remodelling, a cross-sectional study

BackgroundElite athletes have been the subject of great interest, but athletes at an intermediate level of physical activity have received less attention in respect to the presence of cardiac enlargement and/or hypertrophy. We hypothesized that playing football, often defined as demanding less endurance components than running or cycling, would still induce remodelling similar to sports with a dominating endurance component.Methods23 male football players, age 25+/− 3.9 yrs. underwent exercise testing, 2D- and 3D- echocardiography and cardiac magnetic resonance (CMR). The results were compared with a control group of engineering students of similar age. The athletes exercised 12 h/week and the control subjects 1 h/week, p < 0.001.ResultsThe football players achieved a significantly higher maximal load at the exercise test (380 W vs 300 W, p < 0.001) as well as higher calculated maximal oxygen consumption, (49.7 vs 37.4 mL x kg− 1 x min− 1, p < 0.001) compared to the sedentary group. All left ventricular (LV) volumes assessed by 3DEcho and CMR, as well as CMR left atrial (LA) volume were significantly higher in the athletes (3D-LVEDV 200 vs 154 mL, CMR-LVEDV 229 vs 185 mL, CMR-LA volume 100 vs 89 mL, p < 0.001, p = 0.002 and p = 0.009 respectively). LVEF and RVEF, LV strain by CMR or by echo did not differentiate athletes from sedentary participants. Right ventricular (RV) longitudinal strain, LA and right atrial (RA) strain by CMR all showed similar results in the two groups.ConclusionModerately trained intermediate level football players showed anatomical but not functional cardiac remodelling compared to sedentary males.

Variation in Leishmania chemokine suppression driven by diversification of the GP63 virulence factor.

Leishmaniasis is a neglected tropical disease with diverse outcomes ranging from self-healing lesions, to progressive non-healing lesions, to metastatic spread and destruction of mucous membranes. Although resolution of cutaneous leishmaniasis is a classic example of type-1 immunity leading to self-healing lesions, an excess of type-1 related inflammation can contribute to immunopathology and metastatic spread. Leishmania genetic diversity can contribute to variation in polarization and robustness of the immune response through differences in both pathogen sensing by the host and immune evasion by the parasite. In this study, we observed a difference in parasite chemokine suppression between the Leishmania (L.) subgenus and the Viannia (V.) subgenus, which is associated with severe immune-mediated pathology such as mucocutaneous leishmaniasis. While Leishmania (L.) subgenus parasites utilize the virulence factor and metalloprotease glycoprotein-63 (gp63) to suppress the type-1 associated host chemokine CXCL10, L. (V.) panamensis did not suppress CXCL10. To understand the molecular basis for the inter-species variation in chemokine suppression, we used in silico modeling to identify a putative CXCL10-binding site on GP63. The putative CXCL10 binding site is in a region of gp63 under significant positive selection, and it varies from the L. major wild-type sequence in all gp63 alleles identified in the L. (V.) panamensis reference genome. Mutating wild-type L. (L.) major gp63 to the L. (V.) panamensis sequence at the putative binding site impaired cleavage of CXCL10 but not a non-specific protease substrate. Notably, Viannia clinical isolates confirmed that L. (V.) panamensis primarily encodes non-CXCL10-cleaving gp63 alleles. In contrast, L. (V.) braziliensis has an intermediate level of activity, consistent with this species having more equal proportions of both alleles. Our results demonstrate how parasite genetic diversity can contribute to variation in immune responses to Leishmania spp. infection that may play critical roles in the outcome of infection.

한국성인의 신체활동과 수면 및 이상지질혈증 발생의 연관성: 한국유전체역학조사연구(2001-2012)

The purpose of this study was to analyze the effect on the occurrence of dyslipidemia and to clarify its association with physical activity and sleep duration. This study investigated a total of 3,498 among 10,030 adults(51.7±9.1 years of age) in the Korean Genomic Epidemiology Study(KoGES) community-based cohort study for 12 years between 2001 and 2012. The results showed that the level of sleep duration and physical activity showed a statistically significant relationship based on these distribution characteristics(p<.05). Three models were constructed to analyze the association between physical activity and the incidence risk of dyslipidemia according to adjusting variables. The group with high levels of physical activity had significantly lower incidence risk of dyslipidemia(p<.001) compared to the intermediate level of physical activity and the low physical activity group. Also, there were three models to examine the incidence risk of dyslipidemia in accordance to sleep duration with adjusting variables. Those models presented that more than 8 hours of sleep duration had a higher incidence risk of dyslipidemia than the other two groups(i.e., 6 to 8 hours, below 6 hours/day; p<.05). In conclusion, high physical activity had an effect of statistically significant reduction in the incidence risk of dyslipidemia. Sleep duration between 6 and 8 hours a day could have the most effective impact on reducing the incidence risk of dyslipidemia. Future research should be conducted to investigate more accurately physical activity and sleep conditions through systematic development of survey investigation.

Factors Predicting afterward Childbirth for Infertile Women: The Intensity of Physical Activity

Purpose: The aim of this study was to investigate the intensity of physical activity predicting afterward childbirth for infertile women in order to improve the development of an infertility support.Methods: The complete enumeration data of the National Health Insurance Service of Korea for women who had been diagnosed with infertility in 2016 were analyzed to investigate the predictors of childbirth in 2016–2017. The data were analyzed using descriptive statistics and linear regression with SPSS.Results: When age and body mass index were controlled for, intermediate intense physical activity increased the rate of childbirth, but low or heavy intensity did not.Conclusion: Women who have been diagnosed with infertility should be given advice to engage in intermediate levels of physical activity in order to increase their chances of having a child.

Potency of BNT162b2 and mRNA-1273 vaccine-induced neutralizing antibodies against severe acute respiratory syndrome-CoV-2 variants of concern: A systematic review of in vitro studies.

SummaryBNT162b2 and mRNA‐1273 are two types of mRNA‐based vaccine platforms that have received emergency use authorization. The emergence of novel severe acute respiratory syndrome (SARS‐CoV‐2) variants has raised concerns of reduced sensitivity to neutralization by their elicited antibodies. We aimed to systematically review the most recent in vitro studies evaluating the effectiveness of BNT162b2 and mRNA‐1273 induced neutralizing antibodies against SARS‐CoV‐2 variants of concern. We searched PubMed, Scopus, and Web of Science in addition to bioRxiv and medRxiv with terms including ‘SARS‐CoV‐2’, ‘BNT162b2’, ‘mRNA‐1273’, and ‘neutralizing antibody’ up to June 29, 2021. A modified version of the Consolidated Standards of Reporting Trials (CONSORT) checklist was used for assessing included study quality. A total 36 in vitro studies meeting the eligibility criteria were included in this systematic review. B.1.1.7 (Alpha), B.1.351 (Beta), P.1 (Gamma), and B.1.617.2 (Delta) are four SARS‐CoV‐2 variants that have recently been identified as variants of concern. Included studies implemented different methods regarding pseudovirus or live virus neutralization assays for measuring neutralization titres against utilized viruses. After two dose vaccination by BNT162b2 or mRNA‐1273, the B.1.351 variant had the least sensitivity to neutralizing antibodies, while B.1.1.7 variant had the most sensitivity; that is, it was better neutralized relative to the comparator strain. P.1 and B.1.617.2 variants had an intermediate level of impaired naturalization activity of antibodies elicited by prior vaccination. Our review suggests that immune sera derived from vaccinated individuals might show reduced protection of individuals immunized with mRNA vaccines against more recent SARS‐CoV‐2 variants of concern.

Generation of excitatory and inhibitory neurons from common progenitors via Notch signaling in the cerebellum.

Brain neurons arise from relatively few progenitors generating an enormous diversity of neuronal types. Nonetheless, a cardinal feature of mammalian brain neurogenesis is thought to be that excitatory and inhibitory neurons derive from separate, spatially segregated progenitors. Whether bi-potential progenitors with an intrinsic capacity to generate both lineages exist and how such a fate decision may be regulated are unknown. Using cerebellar development as a model, we discover that individual progenitors can give rise to both inhibitory and excitatory lineages. Gradations of Notch activity determine the fates of the progenitors and their daughters. Daughters with the highest levels of Notch activity retain the progenitor fate, while intermediate levels of Notch activity generate inhibitory neurons, and daughters with very low levels of Notch signaling adopt the excitatory fate. Therefore, Notch-mediated binary cell fate choice is a mechanism for regulating the ratio of excitatory to inhibitory neurons from common progenitors.

How the kinetic behavior of organic chickens affects productive performance and blood and meat oxidative status: a study of six poultry genotypes

The aim of this study was to analyze the relationship between the kinetic behavior, carcass characteristics, oxidative status (blood and meat), and meat fatty acid profiles of 6 organically reared slower growing chicken genotypes (SrG). One hundred male chickens of 6 SrG were used: Ranger Classic (RC), Ranger Gold (RG), Rowan Ranger (RR), RedJA (RJ), CY Gen 5 JA87 (CY), and M22 × JA87 (M). Twenty chickens/genotype were selected to analyze behavior, while, 15 individuals were slaughtered and different traits were analyzed in the blood and drumstick meat. The variables were grouped into different principal components: kinetic activity (PC1, with explorative attitude as the highest score), productive performance (PC2, carcass and head/feet yields), blood (PC3, carbonyls, and TBARS) and meat (PC6, thiols, and TBARS) markers, technological traits (PC4, pH, and color), proximate meat composition (PCA5, moisture, lipids, protein, and ash), fatty acid profile, and nutritional indexes (PC7, IP, and PUFAn-3). Uni- and bivariate analyses showed a strong positive association between kinetic behaviors and blood and meat oxidation and a medium positive association with fatty acid profile and nutritional indexes, whereas a negative association was found between productive performance loads and the technological traits of meat. Generalized linear models showed that all PCs were influenced by genotype. In particular, CY and M resulted as less active genotypes; conversely, RR showed more kinetic activity, whereas RJ, RG, and RC exhibited intermediate levels of activity. Cluster analysis of kinetic behavior and blood or meat oxidative status highlighted 2 groups: nonwalking (NW: CY and M) and walking (W: RC, RG, RR, and RJ) animals. However, in the W group, another was visualized, constituted by genotypes with high kinetic activity resulting in the worst oxidative balance (Walking not trained-genotypes, Wnt: RR and RJ). The present results confirmed that the kinetic behavior of SrG genotypes is negatively correlated with productive performance. Furthermore, a significant association between kinetic behavior and blood (positively correlated) or meat (negatively correlated) oxidative status was noted. Such differences are mainly due to the intrinsic response of the genotypes used (i.e., training-walking capacity).